Information and Communication Technologies (ICT) offer a strong potential for innovation, both for enterprises as well as for the Society. The successful management of these innovations is not only depending on technical factors, but also, and probably first, on the take up and the integration of these innovations by organizations and individuals in their activities. The goal of SPIRAL 2005 is to identify, to analyze and to study such factors favoring the integration of ICT-based innovations within organizations. Through different experimentations and business case reports, each speaker will discuss the different facets of the integration of information systems within business processes, the importance of a global data dictionary (ontology) and, finally, the importance of the IT/business alignment within the context of an IT Governance strategy. These success factors will be presented through different cases arising from different sectors : bank and finance, public administration, e-business and building sector.