The workshop will be held as part of INTEROP'05. System Interoperability is a growing interest area, because of the continuously growing need of integration of new, legacy and evolving systems, in particular in the context of networked businesses and eGovernment. Modelling approaches, including ontologies, object-oriented modeling, enterprise modeling architectural modeling, provide useful tools for this problem. However, they only provide notations to express common or different concepts of the enterprises considered. A complete approach must also include methods and tools supporting these methods. This workshop explores the tenet that a model-driven approach, based on model transformations, can be fruitfully developed to help solve this problem. This workshop solicits input from researchers, technology providers and users with experience in solutions and problems related to technical and semantic interoperability of enterprise systems. Basic technologies that are in the focus of the workshop are: object and component technologies, ontologies, software architecture, model driven development, autonomous computing, agent-based computing, web services, business process modeling, enterprise modeling, provided they are applied to organization integration. A special point of interest is the dynamic, on-the-fly integration of new enterprises in a network of enterprises. The goal is to share experience, consolidate successful techniques, and identify the most promising solutions and try to integrate them in a comprehensive solution. This will lead to the identification of critical open problems.